CellKey™ Product Applications

The CellKey™ System enables a broad range of applications that provide unique biorelevant response data. Assay implementation is simple, and facilitates a comprehensive pharmacological evaluation of all receptors within adherent or non-adherent cell lines and primary cells.

Receptor Panning

A unique application enabled by the ability of the CellKey™ System to reliably quantify activation of endogenous receptors — with one protocol. This application allows investigators to easily screen disease-relevant cell types for functionally active target receptors. Learn more.

Signal Pathway Identification & Deconvolution

The CellKey™ System provides a universal assay that can monitor the activity of different classes of known and orphan receptors, and differentiate between their signaling mechanisms. Learn more.

Hit Identification and Pharmacological Profiling

The CellKey™ System offers a single platform for conducting pharmacological evaluation of ligands across a spectrum of receptors and cell types irrespective of the coupling mechanism. Learn more.

Some of the diverse types of endogenous receptors measured by the CellKey™ System to date are listed in the following table.

CellKey™ pharmacological analysis has been done in the context of cell lines and primary cells, some of which are listed below:

Cell Lines A10 A431 A549 CHO COS-7 HEK 293 HeLa HL60 HUVEC Jurkat MCF-7 MDA-MB-231 N2A PC-3 RMS13 SH-SY5Y TE671 THP-1 U-937 U2-0S V79

Primary Cells Mast Cells Neutrophils Osteoblasts Prostate Cells

  TOP