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Thank you for your interest in MDS Analytical Technologies' CellKey™ System. Documents marked with an asterisk (*) contain customer approved collaboration data or new research data, thus require a simple, one-time registration. Or, if you have already registered, you must be logged in.

Application Bulletin

		Application Bulletin 8: Label-Free Analysis of Primary Cells *      [show details]
		This bulletin discusses the ability to measure endogenous levels of receptors in primary cells, and specifically a study performed in collaboration with Lonza to screen primary isolates of human skeletal muscle myoblast (HSMM) cell line. We demonstrate the ease to identify targets, through receptor panning, and to quickly develop robust assays to further validate the targets and perform pharmacology
		Application Bulletin 7: Label Free Screening of Endogenous Targets *      [show details]
		This bulletin describes the screening of the LOPAC1280 library for detection of agonist and antagonists of endogenous receptors expressed on the HeLa cell line. Additionally, follow-up pharmacology was performed.
		Application Bulletin 6: Monitoring functional inhibition of a cell surface receptor using RNA interference *      [show details]
		This bulletin describes a straightforward and effective method for monitoring functional knockdown of an endogenous cell surface receptor using the CellKey™ System and transiently transfected small interfering ribonucleic acids (siRNAs).
		Application Bulletin 5: Analyzing endogenous receptors in non-adherent cell lines and primary cells with the CellKey™ Small Sample 96W microplate *      [show details]
		This bulletin describes the benefits of using the new CellKey™ Small Sample 96W microplate for investigating endogenous receptor function in non-adherent cell lines and primary cells.
		Application Bulletin 4: Endogenous receptor evaluations: receptor subtyping and Schild analysis *      [show details]
		This bulletin describes the versatility of the CellKey™ System in determining the subtype and complex pharmacological properties of an endogenously expressed receptor.
		Application Bulletin 3: Deconvolution of signal transduction pathways *      [show details]
		This bulletin describes application of this technology to deconvolution of receptor-mediated signal transduction with a focus on G-protein coupled receptors (GPCRs) and tyrosine kinase receptors (TKRs).
		Application Bulletin 2: Identifying the G-protein coupling mechanism of GPCRs *      [show details]
		This bulletin describes application of this technology to identification of the G-protein coupling mechanism of G-protein coupled receptors (GPCRs).
		Application Bulletin 1: Receptor Panning *      [show details]
		Receptor Panning Application Bulletin — this bulletin describes the application of the CellKey™ System to screening for functional endogenous receptors in cell types of interest.

Documents marked with an asterisk (*) require a simple, one-time registration.
Or, if you have already registered, you must be logged in.